Chelsea was born in Little Rock, Arkansas during her father's first term as Governor of Arkansas. She attended public schools there until her father's election to the Presidency of the United States at which time she attended and graduated from the private Sidwell Friends School in Washington, D.C. She continued her education at Stanford University, receiving a bachelor's degree in history, and earned master's degrees from University College, Oxford, and Columbia University's Mailman School of Public Health. She is currently pursuing a doctoral degree at the Robert F. Wagner Graduate School of Public Service at New York University. She worked for Avenue Capital Group, and serves on the board of the School of American Ballet.
On July 31, 2010, Clinton married investment banker Marc Mezvinsky in Rhinebeck, New York.